• In summary activated A AR exacerbated the reverse transport

  2022-09-01

  

  In summary, activated A2AR exacerbated the reverse transport function of endothelial EAATs through a direct or indirect pathway depending on PKA and glutamate levels in response to OGD in vitro, but A2AR inhibition quickly restored the normal transport function. Moreover, the key mechanisms by which

• Milnacipran HCl In this study we investigated the

  2022-09-01

  

  In this study, we investigated the contribution of GCK, G6PC, and PCK expression to glycemia in diabetes. We examined liver tissue from 40 obese subjects: 12 had normal glucose tolerance (NGT) and 28 had type 2 diabetes. Materials and methods Results Discussion This study aimed to investig

• In the liver ghrelin has

  2022-09-01

  

  In the liver, ghrelin has opposite effects to insulin on the expression of the enzyme PEPCK, thereby promoting gluconeogenesis and also causing a decrease in glucose uptake and fatty protease activated receptor oxidation (Rigault et al., 2007). Ghrelin also stimulates hepatic lipogenesis de novo in

• Based upon the present findings it is tempting to

  2022-09-01

  

  Based upon the present findings, it is tempting to imagine that selective, and especially stable blood–brain barrier (BBB) penetrating GalR1 antagonists might be useful as drugs for acute suppression of appetite. While this may be possible, previous studies using nonspecific galanin antagonists yiel

• Most of the above mechanisms are implicated in attenuation o

  2022-09-01

  

  Most of the above mechanisms are implicated in attenuation of myocardial I/R injury. However, the role of GalR2 receptor activation in cardioprotection remains unclear because of the lack of receptor subtype selectivity of peptides G2 and G3. It has been shown that Ala5-galanin (2–11) (G4) has a hig

• SYN-117 So what makes a FFAR agonist different and interesti

  2022-09-01

  

  So what makes a FFAR1 agonist different and interesting? As shown in the , the cellular mechanism is different from those of present insulin-releasing pharmacotherapies—namely the secretion initiators (sulphonylureas and meglitinides) and the incretin-based secretion potentiators (glucagon-like pept

• Cy5 maleimide (non-sulfonated) A species specific diverse nu

  2022-09-01

  

  A species-specific diverse number of FPPS genes are present in insect genomes (Zhang and Li, 2008, Cusson et al., 2006). The genome of the yellow fever mosquito Aedes aegypti contains a single FPPS gene (AaFPPS) that is highly expressed in the CA (Nouzova et al., 2011). FPPS catalytic activity in th

• Acknowledgments br Introduction Stress plays a key role

  2022-09-01

  

  Acknowledgments Introduction Stress plays a key role in the etiology and/or exacerbation of major depressive disorder characterized by loss of energy, feelings of hopelessness and anhedonia [1]. Ample evidence clearly suggests that endocannabinoids (eCBs) participate in stress-associated neurona

• Epigenetic inheritance is regarded as

  2022-09-01

  

  Epigenetic inheritance is regarded as the genetic modification of NVP-BHG712 australia that affects gene expression and related processes of other DNAs but does not directly change the DNA coding sequence [18]. Epigenetic inheritance includes DNA methylation, histone modification, and noncoding RNA

• br Application of TIRFM to visualizing exocytosis TIRFM

  2022-09-01

  

  Application of TIRFM to visualizing exocytosis TIRFM was first used to visualize exocytosis from large secretory granules from chromaffin Mesoridazine (Steyer et al., 1997). Before that, visualization of secretory organelle was strictly limited to a few exceptions, such as mast cell of mutant mic

• br Histamine H R Many of

  2022-08-31

  

  Histamine H3R Many of the highlight H3R ligands have been described as suitable pharmacological tools for in vitro or in vivo studies and are designated here. The number of ligands and structural categories is huge, and a number of inclusive reviews of the SAR and properties of H3R ligands have b

• amitriptyline hydrochloride Nuclear factor erythroid like NF

  2022-08-31

  

  Nuclear factor erythroid 2-like-2 (NFE2L2; hereafter NRF2) plays a crucial role in the basal and inducible expressions of multiple cytoprotective genes in response to electrophilic and oxidative stress [23]. The cytosolic actin-binding protein Kelch-like ECH-associated protein 1 (KEAP1) primarily re

• Some biguanides can cross the mitochondrial membrane

  2022-08-31

  

  Some biguanides can cross the mitochondrial membrane and increase L-lactate formation by inhibiting oxidative Coumarin [34]. On the other hand, it has also been reported that levels of fasting plasma lactate in T2DM patients are similar regardless of whether or not metformin is administered [35] an

• The average pregnancy rate in this work was

  2022-08-30

  

  The average pregnancy rate in this work was 60.1%; similar results have been reported with the same estrus synchronization treatment (58% pregnancy rate) [26]. Later studies also showed that the pregnancy rate was 56.9 and 51.1%, with FTAI and estrous detection, respectively [34,35]. Although that t

• To maintain low Glu concentrations in the

  2022-08-29

  

  To maintain low Glu concentrations in the synaptic cleft below the affinity of its receptors, this amino 57 9 synthesis is rapidly removed from the extracellular space by a family of sodium-dependent high-affinity transport systems located mainly in the plasma membrane of perisynaptic astrocytes, an

14718 records 373/982 page Previous Next First page 上5页 371372373374375 下5页 Last page