• TRAPP Transport Protein Particle complexes share a

  2022-01-03

  

  TRAPP (Transport Protein Particle) complexes share a common core architecture and function in Penciclovir Sodium receptor and autophagy (Kim et al., 2016). In yeast, the core complex has GEF activity for the Rab1 ortholog Ypt1. The larger TRAPPII and III complexes include regulatory subunits implic

• 2'-O-Methyl-ATP synthesis br Conflict of interest br Ack

  2022-01-03

  

  Conflict of interest Acknowledgment This work was supported by National Program on Key Basic Research Project of China (No. 2013CB127305); The National Natural Science Foundation of China (No. 314020785); Hubei Provincial Creative Team Project of Agricultural Science and Technology (No. 2007-6

• In summary through medicinal chemistry design and computer a

  2022-01-03

  

  In summary, through medicinal chemistry design and computer-assisted conformational modeling, the initial lead was evolved into a series of dihydrobenzofuran derivatives, , as potent GPR119 agonists. Optimization of general structure at various regions of the molecule, including the substituent on

• The HIV genome encodes for a

  2022-01-03

  

  The HIV-1 genome encodes for a variety of viral proteins necessary for target cell entry and viral replication. gp120 is an HIV-1 envelope glycoprotein that mediates viral particle entry by binding to cell surface receptor CD4 and co-receptors CXCR4 and/or CCR5 depending on viral tropism. While CXCR

• Morin is a flavonoid that has shown to have

  2022-01-03

  

  Morin is a flavonoid that has shown to have effective anti-inflammatory and anti-tumor function [118]. Morin was able to block the activation of NF-κB pathway by ROS and inflammatory cytokines, preventing a signaling cascade resulting in cell death [121]. Morin exerted its control over the signaling

• br Membrane transporters as a novel therapeutic target in

  2022-01-03

  

  Membrane transporters as a novel therapeutic target in pediatric TBI The concept of targeting membrane transporters began with identifying a neuroprotective drug and a corresponding transporter inhibitor. Somewhat serendipitously, we discovered that N-acetylcysteine (NAC), a cysteine donor for GS

• SGLT inhibitors have been accepted

  2022-01-03

  

  SGLT-2 inhibitors have been accepted as a new class of antidiabetic agent (Kurosaki and Ogasawara, 2013). They limit renal glucose reabsorption and promote urinary excretion of glucose, thereby reducing plasma glucose levels (de Leeuw and de Boer, 2016, Jojima et al., 2016, Pérez López et al., 2010,

• leukotriene receptor agonist br Presenilins and apoptosis Ap

  2022-01-03

  

  Presenilins and apoptosis Apoptosis, also known as programmed cell death, has a critically important role in tissue homeostasis, development, normal ageing and the pathogenesis of several diseases, including cancer and neurological disorders. The presenilins were first linked to apoptosis when ce

• The results obtained here in int

  2022-01-03

  

  The results obtained here in int-Gr+/+ and int-Gr−/− mice suggested that Gr is required to maintain basal level of Fgf15 expression in the ileum, whereas DEX treatment is able to reduce Fgf15 mRNA in a Gr-independent manner. In previous in vitro studies we have already shown that GC are able to affe

• EZH mutations or amplifications have

  2022-01-03

  

  EZH2 mutations or amplifications have been found in a broad spectrum of human cancers including B cell lymphoma, ovarian cancer, breast cancer, melanoma, bladder cancer, gastric cancer, and other cancers (Kim and Roberts, 2016). Given the evidence of EZH2 as a cancer driver, numerous efforts have be

• br Discussion Considering cardiovascular risk factors there

  2022-01-03

  

  Discussion Considering cardiovascular risk factors, there was a significant difference in prevalence of dyslipidemia in both groups, 57.5% in HIV-infected stroke patients compared to 8.9% in the HIV-uninfected patients. These results are similar to that of Chow et al. who found a dyslipidemia pre

• br Materials and methods br Results To

  2022-01-03

  

  Materials and methods Results To examine the time and organ specific effect of normal photoperiod and dark environment on the cdk7 of different SlHXKs and on the enzyme activities, these parameters were determined in different leaf positions of tomato plants. Under control conditions, transcr

• Artemisinine Currently the computational chemical biology ha

  2021-12-31

  

  Currently, the computational chemical biology has been applied in hepatitis B antiviral drug discovery research [18]. Tan et al. explored oxime ethers as HBV inhibitors by docking and screening [19]. Allen et al. clarified the resistance of HBV to the nucleoside drug lamivudine [20]. The results sug

• br Conclusion We conducted single marker association and hap

  2021-12-31

  

  Conclusion We conducted single-marker association and haplotype association analyses of genetic mutations in porcine SLA-DOB and CD4 genes with T-lymphocyte subsets, cytokines, and HhAntag in pregnant Landrace sows and obtained the SNPs and insertion that significantly affected the immunity trai

• br Conclusion The wild study reports seasonal variations in

  2021-12-31

  

  Conclusion The wild study reports seasonal variations in reproductive physiology, behavior and Letermovir plasticity at different age stages in wild-caught Mongolian gerbils. The gerbils in breeding seasons have more mature sexual development, higher exploratory behavior, higher novelty preferen

14594 records 498/973 page Previous Next First page 上5页 496497498499500 下5页 Last page