• The HIV genome encodes for a

  2022-01-03

  

  The HIV-1 genome encodes for a variety of viral proteins necessary for target cell entry and viral replication. gp120 is an HIV-1 envelope glycoprotein that mediates viral particle entry by binding to cell surface receptor CD4 and co-receptors CXCR4 and/or CCR5 depending on viral tropism. While CXCR

• Morin is a flavonoid that has shown to have

  2022-01-03

  

  Morin is a flavonoid that has shown to have effective anti-inflammatory and anti-tumor function [118]. Morin was able to block the activation of NF-κB pathway by ROS and inflammatory cytokines, preventing a signaling cascade resulting in cell death [121]. Morin exerted its control over the signaling

• br Membrane transporters as a novel therapeutic target in

  2022-01-03

  

  Membrane transporters as a novel therapeutic target in pediatric TBI The concept of targeting membrane transporters began with identifying a neuroprotective drug and a corresponding transporter inhibitor. Somewhat serendipitously, we discovered that N-acetylcysteine (NAC), a cysteine donor for GS

• SGLT inhibitors have been accepted

  2022-01-03

  

  SGLT-2 inhibitors have been accepted as a new class of antidiabetic agent (Kurosaki and Ogasawara, 2013). They limit renal glucose reabsorption and promote urinary excretion of glucose, thereby reducing plasma glucose levels (de Leeuw and de Boer, 2016, Jojima et al., 2016, Pérez López et al., 2010,

• leukotriene receptor agonist br Presenilins and apoptosis Ap

  2022-01-03

  

  Presenilins and apoptosis Apoptosis, also known as programmed cell death, has a critically important role in tissue homeostasis, development, normal ageing and the pathogenesis of several diseases, including cancer and neurological disorders. The presenilins were first linked to apoptosis when ce

• The results obtained here in int

  2022-01-03

  

  The results obtained here in int-Gr+/+ and int-Gr−/− mice suggested that Gr is required to maintain basal level of Fgf15 expression in the ileum, whereas DEX treatment is able to reduce Fgf15 mRNA in a Gr-independent manner. In previous in vitro studies we have already shown that GC are able to affe

• EZH mutations or amplifications have

  2022-01-03

  

  EZH2 mutations or amplifications have been found in a broad spectrum of human cancers including B cell lymphoma, ovarian cancer, breast cancer, melanoma, bladder cancer, gastric cancer, and other cancers (Kim and Roberts, 2016). Given the evidence of EZH2 as a cancer driver, numerous efforts have be

• br Discussion Considering cardiovascular risk factors there

  2022-01-03

  

  Discussion Considering cardiovascular risk factors, there was a significant difference in prevalence of dyslipidemia in both groups, 57.5% in HIV-infected stroke patients compared to 8.9% in the HIV-uninfected patients. These results are similar to that of Chow et al. who found a dyslipidemia pre

• br Materials and methods br Results To

  2022-01-03

  

  Materials and methods Results To examine the time and organ specific effect of normal photoperiod and dark environment on the cdk7 of different SlHXKs and on the enzyme activities, these parameters were determined in different leaf positions of tomato plants. Under control conditions, transcr

• Artemisinine Currently the computational chemical biology ha

  2021-12-31

  

  Currently, the computational chemical biology has been applied in hepatitis B antiviral drug discovery research [18]. Tan et al. explored oxime ethers as HBV inhibitors by docking and screening [19]. Allen et al. clarified the resistance of HBV to the nucleoside drug lamivudine [20]. The results sug

• br Conclusion We conducted single marker association and hap

  2021-12-31

  

  Conclusion We conducted single-marker association and haplotype association analyses of genetic mutations in porcine SLA-DOB and CD4 genes with T-lymphocyte subsets, cytokines, and HhAntag in pregnant Landrace sows and obtained the SNPs and insertion that significantly affected the immunity trai

• br Conclusion The wild study reports seasonal variations in

  2021-12-31

  

  Conclusion The wild study reports seasonal variations in reproductive physiology, behavior and Letermovir plasticity at different age stages in wild-caught Mongolian gerbils. The gerbils in breeding seasons have more mature sexual development, higher exploratory behavior, higher novelty preferen

• br Discussion CHO K cell

  2021-12-31

  

  Discussion CHO-K1 cell lines stably expressing each of the NH2-terminal isoforms of the human glycine reuptake transporter GlyT1 have been developed. GlyT1 uptake assays have been validated for two lines for each isoform, one low and high expressor. Expression levels in the lines have been confir

• The inhibition of NSAIDs towards GLOI

  2021-12-31

  

  The inhibition of NSAIDs towards GLOI provides a direction for the development of novel effective GLOI inhibitors. Although the inhibitory activity of indomethacin was determined and the interactions between it cotransporter and GLOI were probed by NMR titration experiments, no detailed inhibitory

• Accordingly it is tempting to speculate that the

  2021-12-31

  

  Accordingly, it is tempting to speculate that the maintenance of a stimulus representation in the A2 state for a short period of time after the presentation of a specific stimulus (i.e. self-generated priming) may rely upon GluR-A-dependent synaptic plasticity. If this were the case, GluR-A Methimaz

14246 records 475/950 page Previous Next First page 上5页 471472473474475 下5页 Last page