• Initially we carried out gap FRAP experiments

  2021-12-02

  

  Initially, we carried out gap-FRAP experiments using the two-photon configuration of the confocal microscope. A SR101-positive astrocyte was targeted and a 5 × 5 μm square area was exposed to a laser illumination (5 flashes of 5 s each during 25 s). This procedure resulted in a bleaching of this ast

• Numerical models of blood regulation

  2021-12-02

  

  Numerical models of blood regulation provide insight into the interaction of the cellular-level and macro-scale phenomena studied in silico, a term referring to computer simulations of the dynamics of complex biological systems as opposed to in vivo or in vitro experimental studies. These in silico

• The role of cell to cell interactions in coordinating

  2021-12-02

  

  The role of cell-to-cell interactions in coordinating the cells’ behaviour to ensure an appropriate anterior pituitary hormone response is receiving increasing attention. Anterior pituitary LY 2109761 sale interact with neighbouring cells through junctional complexes. As their name implies, the com

• In conclusion starting from the weakly potent GSM exploratio

  2021-12-02

  

  In conclusion, starting from the weakly potent GSM , exploration of various spacer groups between the triazole ring and the aromatic Fmoc-His(Boc)-OH.CHA led to the discovery of a new series of potent gamma secretase modulators, with an improved drug-like profile—compared with the originally reporte

• br Conclusions In this study we discovered that the

  2021-12-02

  

  Conclusions In this study, we discovered that the G-quadruplex (Q1) formed by S1 sequence in the upstream region of the transcription start site of c-Myb gene functioned as a positive transcriptional regulator, which was different from the most cases that G-rich sequences functioned to impair the

• Beta-Lapachone Our results further indicate that low express

  2021-12-02

  

  Our results further indicate that low expression of p300/CBP in CRC is directly associated with poor clinical therapeutic outcome of 5-FU treatment, potentially providing a new set of biomarkers to predict chemo-sensitivity. Although the ability of low expression of p300/CBP to predict poor prognosi

• br Conclusion In this report we describe the synthesis and

  2021-12-02

  

  Conclusion In this report, we describe the synthesis and evaluation of oxadiazole-based GSK3 inhibitors. Occupation of the ATP-binding pocket in its entirety led to the identification of several potent and selective compounds. These compounds are characterized by IC50 values in the low nanomolar

• To further investigate its role in

  2021-12-02

  

  To further investigate its role in stresses tolerance, OsGly I was overexpressed in transgenic rice. qRT-PCR and zymologic determination showed that Glutathione (GSH/GSSG/Total) Fluorometric Assay Kit level of OsGly I and the glyoxalase I activity were significantly increased to different extent in

• Recent research reveals that human alkyladenine DNA glycosyl

  2021-12-02

  

  Recent research reveals that human alkyladenine DNA glycosylase (hAAG) is an important protein enzyme which can specifically recognize and excise a variety of alkylated purines and deoxyinosine from DNA [12]. hAAG plays pivotal roles in maintaining genomic integrity, and it is involved in Bioactive

• Introduction Carbohydrates are some of the most stereochemic

  2021-12-02

  

  Introduction Carbohydrates are some of the most stereochemically complex biological molecules found in nature. In addition to their energetic and structural roles in living systems, their role when covalently linked to proteins is critically important in a myriad of molecular recognition processes.

• Ghrelin contains an n octanoylation

  2021-12-01

  

  Ghrelin contains an n-octanoylation at its Ser3 residue (Kojima et al., 1999). While des-acyl ghrelin is found in high concentrations in the blood, only the lipidated form is active at GHSR (Bednarek et al., 2000). We previously showed that ghrelin interacts with the membrane via its lipid modificat

• Inhibitors against the proteasome a component of the ubiquit

  2021-12-01

  

  Inhibitors against the proteasome, a component of the ubiquitin-proteasome pathway that degrades cellular proteins, provide a new strategy for targeting the 26S proteasome [25]. Proteasome inhibitors can exhibit potent anti-cancer effects against different tumor H 89 and were shown to induce apoptos

• In summary metagenome sequencing of paddy soil

  2021-12-01

  

  In summary, metagenome sequencing of paddy soil was performed with 55.68 Gb sequences, and subsequent data mining was performed for functional profiles and metabolic pathways. Several GH family proteins, such as amylases, cellulases, xylanases, and galactosidases, were explored in the paddy soil met

• A mutation in stearoyl coenzyme

  2021-12-01

  

  A mutation in stearoyl coenzyme A desaturase 1 gene was reported to reduce sebum production and monounsaturated fatty acids (MUFA) synthesis in mice, which was accompanied with impaired clearance of gram-positive bacteria-induced skin infection (Georgel et al., 2005). Interestingly, gram-positive ba

• The third group also included samples belonging to

  2021-12-01

  

  The third group also included samples belonging to subjects with undetectable viraemia, for which the negative or persistence of the indeterminate WB result in subsequent samples indicated a non-HIV infection. In this subgroup, the VITROS HIV Combo test (as well as the other two tests) was negative

14241 records 492/950 page Previous Next First page 上5页 491492493494495 下5页 Last page