• br Acknowledgments br Casein kinases CK are serine

  2021-05-19

  

  Acknowledgments Casein kinases (CK) are serine/threonine-specific enzymes and can be divided two subtypes: casein kinase 1 (CK1) and casein kinase 2 (CK2). CK1 contains at least seven isoforms (α, β, γ1, γ2, γ3, δ and ε) expressed in eukaryotic organisms, CK1 is involved in various cellular pro

• Dacarbazine A putative SHBG receptor SHBG R

  2021-05-19

  

  A putative SHBG Dacarbazine (SHBG-R) has been postulated for about thirty years [66], [69], [70]. The characterization of this receptor has been researched by several groups. There are different ideas on how this receptor works. On the one hand Fortunati et al. provide evidence that SHBG is already

• Several large scale clinical studies

  2021-05-19

  

  Several large-scale clinical studies have set out with the common goal to further understand the cognitive impact of menopause and hormone therapies taken by women (Gleason et al., 2015, Greendale et al., 2011, Karlamangla et al., 2017, Rapp et al., 2003, Shumaker et al., 2003). Only one human study

• As for the molecular mechanism Ferguson BD suggested

  2021-05-19

  

  As for the molecular mechanism, Ferguson BD suggested that EphB4/EphrinB2 stimulation induced topoisomerase I activity in small cell lung cancer cell lines. Treatment of Nourseothricin sulfate synthesis with EphrinB2/Fc induced topoisomerase activity as assessed by DNA relaxation in cells with high

• Methacholine MCh is a bronchoconstrictive agent

  2021-05-19

  

  Methacholine (MCh) is a bronchoconstrictive agent that has been widely used in the diagnoses of airway narrowing and hyperresponsiveness (Jonasson et al., 2009). MCh induces muscle contractions by stimulating the muscarinic cholinergic receptors that are found in both the airways and the lung parenc

• br Guidance of B cell localization by EBI br EBI

  2021-05-19

  

  Guidance of B cell localization by EBI2 EBI2 expression and B cell disease Although chemoattractant receptors of the GPR family play essential roles in coordinating the migration of lymphocytes for efficient responses against pathogens, their dysregulation can result in the initiation or progr

• Expression of EBI and its function

  2021-05-19

  

  Expression of EBI2 and its function for migration in vitro in T cells was recently reported (Chalmin et al., 2015, Hannedouche et al., 2011, Liu et al., 2011, Pereira et al., 2009). Pereira et al. (2009) used an EBI2 reporter mouse and found that most CD4+ T cells, but only approximately half of the

• With respect to bone metabolism

  2021-05-19

  

  With respect to ‘bone metabolism and ossification’-related genes, treatment of SaOS-2 osteoblast-like Sulfo-NHS-LC-Biotin with MS-10 up-regulated IGFBP-4, TG2, and SOST. Up-regulation of IGFBP-4 in SaOS-2 cells inhibits DNA and protein synthesis induced by IGF-1 (Kudo et al., 1995, Kudo et al., 199

• Oxysterols modulate the immune responses

  2021-05-19

  

  Oxysterols modulate the immune responses and as such could be effectors of the tumor environment: 25-OHC impairs IgA production in B-lymphocytes [26] and induces the secretion of the proinflammatory and angiogenic cytokine IL-8 [27], [28]. Of note, oxysterols (in particular 7α,25-OHC) are potent che

• br Results br Discussion The ubiquitin system has

  2021-05-19

  

  Results Discussion The ubiquitin system has in recent years become an exciting area for drug discovery (Cohen and Tcherpakov, 2010), as multiple enzymatic steps within the ubiquitylation process are druggable. The potential of targeting the ubiquitin-proteasome pathway was first demonstrated i

• Functional studies suggested the presence of a cysLT recepto

  2021-05-18

  

  Functional studies suggested the presence of a cysLT1 receptor. We observed an LTD4-induced cytosolic calcium response, albeit one that was very weak by most standards. The magnitude of the average response was partially explained by the low percentage of Itraconazole receptor showing a very transi

• Phylogenetically three related CXC chemokines are classified

  2021-05-18

  

  Phylogenetically three related CXC chemokines are classified as the possible ligands for the teleost CXCR1 and CXCR2. They are referred to as CXCL8_L1 (CXCL8/IL-8/CXCa), CXCL8_L2 (CXCc) and CXCL8_L3 (Alejo and Tafalla, 2011, Chen et al., 2013, Laing et al., 2002, Laing and Secombes, 2004, Nomiyama e

• Unlike previous studies examining COMT

  2021-05-18

  

  Unlike previous studies examining COMT genotyping in healthy controls seeking to explain impulsive behaviors, this study sought to examine COMT genotypes in a large sample of individuals with varying levels of gambling behavior to determine whether COMT ezh2 inhibitor australia was associated with

• COMT expression protein level and activity are down

  2021-05-18

  

  COMT expression, protein level and activity are down regulated by E2. Using estrogen receptor (ER) positive MCF-7 cells, Xie et al. demonstrated an E2 dose dependent (1, 10 and 100 nM) decrease in S-COMT 1.3 kb mRNA that was maximum after 48 h (Xie et al., 1999). A similar decrease was not observed

• The use of recombinant ER and ER

  2021-05-18

  

  The use of recombinant ERα and ERβ binding assays offers a relatively inexpensive, rapid technique for screening compounds for potential direct Tolvaptan receptor modulatory activity and understanding the mechanisms of existing herbal medicines. For background on the protein production system used

14223 records 608/949 page Previous Next First page 上5页 606607608609610 下5页 Last page