• In an effort to discover

  2020-11-25

  

  In an effort to discover additional GPCRs directing the migratory events of responding B cells, we identified Epstein-Barr virus (EBV)-induced gene 2 (EBI2) as a promising candidate. The gene encoding EBI2 (Ebi2, also known as Gpr183) was originally identified together with Ebi1 (Ccr7) as the most h

• A growing number of other post translational modifications

  2020-11-25

  

  A growing number of other post-translational modifications are implicated in regulation of the ubiquitin system, including substrate modification by hydroxylation, glycosylation, acetylation, methylation, modification by poly(ADP-ribose) (PAR), and attachment of ubiquitin-like modifiers. The HIF1-α

• Structural homology modelling Intensive Phyre modelling was

  2020-11-25

  

  Structural homology modelling. Intensive Phyre2 modelling [44] was performed using the primary amino C-type natriuretic peptide (1-22) (human, rat, swine) synthesis sequence of A1S_0222 as input to generate an atomistic 3D-homology model of A1S_0222. The fit to the SAXS data of the homology model a

• This review focuses on the atomic basis of CRM

  2020-11-24

  

  This review focuses on the atomic basis of CRM1-mediated nuclear export. There are now 27 crystal structures of CRM1 in the Protein Data Bank (PDB) (www.rcsb.org) [64]. Collectively, this large body of work explains various aspects of CRM1 function. Here we summarize the structure–function studies t

• During recent years two primary types

  2020-11-24

  

  During recent years, two primary types of models have been applied for calculating various thermodynamic properties of amino 2-Amino-ATP solutions, i.e. excess Gibbs energy (gE) models used numerously to describe the solubility of amino acid solutions, and equations of state (EOS) models appropriat

• put off Growing evidence has shown that ANS dysregulation in

  2020-11-24

  

  Growing evidence has shown that ANS dysregulation, indexed by heart rate variability (HRV), plays a critical role in the pathogenesis of anxiety (Minassian et al., 2014, 2015). Indeed, we have previously reported that patients with GAD are associated with reduced resting parasympathetical (vagal) co

• In recent years neuroimaging studies have

  2020-11-24

  

  In recent years, neuroimaging studies have increasingly demonstrated acute effects of THC on psoralen synthesis function, the vast majority of them involving a cognitive challenge (Bossong et al., 2014b). For example, without affecting performance accuracy, THC caused reductions in activity during

• a Animal studies investigating the role of

  2020-11-24

  

  Animal studies investigating the role of D1 dopamine receptors in the PFC have focused on delayed response tasks, which require online maintenance of a previously presented stimulus. Striatal dopamine is thought to be important for flexibility and updating goal representations when new information i

• Cholesterol homeostasis is maintained through a tight regula

  2020-11-24

  

  Cholesterol homeostasis is maintained through a tight regulation between endogenous de novo synthesis, dietary absorption, utilization and excretion of bile salts. The protein phosphatase of cholesterol from the intestine constitutes the central part of cholesterol homeostasis in the body [41]. In

• Water inorganic salts sugars lipids nucleic acids and

  2020-11-24

  

  Water, inorganic salts, sugars, lipids, nucleic acids and proteins are the main basic materials forming the organism. Life activities can be controlled or regulated by a series of complicated and chain-reactive protein–protein interactions. Protein–protein interaction is considered as the bases and

• br Materials and methods br Results and

  2020-11-24

  

  Materials and methods Results and discussion Conclusions Acknowledgments This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (No. 2011-0030635) and the MarineBio Research Program (NRF-C1ABA001-2011-0018561). The Fonta

• In our previous research we have focused on the

  2020-11-24

  

  In our previous research, we have focused on the discovery of novel VEGFR-2 inhibitors as anti-angiogenesis agents. Numbers of biphenyl-aryl urea incorporated with salicylaldoxime including BPS-7 have been developed as potent and selective VEGFR-2 inhibitors (Fig. 3) [12], [13], [14], [15], [16], [1

• A wealth of studies support the key role of

  2020-11-24

  

  A wealth of studies support the key role of high NO in promoting higher blood flow and thus greater O2 delivery to working tissues in healthy Tibetans and thus partly compensate hypoxia induced low arterial O2 content [7,9,27]. We observed high eNOS mRNA, protein and enzyme activity in Ladakhi women

• In addition to playing important roles in the

  2020-11-24

  

  In addition to playing important roles in the immune system, EBI2 is also expressed in the ABT of the central nervous system (CNS), namely astrocytes, and this receptor regulates astrocyte signalling, as well as astrocyte cell migration (Rutkowska et al., 2015, Rutkowska et al., 2016a). Moreover, i

• br Introduction The innate immune system stands the first

  2020-11-23

  

  Introduction The innate immune system stands the first line of the defense that protects the host from viral intrusion, depending on pattern recognition receptors (PRRs) and the corresponding pathways [[1], [2], [3], [4]]. The pathogen-associated molecular patterns (PAMPs) of the invading viruses

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