• br Acknowledgements This research was supported by FAPERJ Fu

  2020-08-08

  

  Acknowledgements This research was supported by FAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (nº E-26/203.551/2015). R.I.S. is a CNPq research fellow. This study was financed in part by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).

• In our model H deposition is required

  2020-08-07

  

  In our model, H3.3 deposition is required for DNA repair synthesis, which could be important to maintain chromatin integrity over long repair patches and also allow for the movement of the D-loop by providing structural stability. The unwinding of the DNA, as in transcription, generates torsional st

• It was recently shown that

  2020-08-06

  

  It was recently shown that the IPF patient-derived ECM could stimulate lung fibroblasts to express genes encoding ECM proteins detected in IPF tissue, strongly supporting the concept that the abnormal ECM components accumulated within fibrotic lung might act as positive-feedback stimuli for the deve

• br Conclusion br Limitations br Conflict of

  2020-08-06

  

  Conclusion Limitations Conflict of interest Financial disclosure The research was supported by National Institute of Mental Health and Neuro Sciences (NIMHANS)Intramural Research Grant ID NIMH/PROJ-RSM/545/2014-15. India. Acknowledgments Introduction Increased central and peripher

• Furthermore our sample preparation uses a

  2020-08-06

  

  Furthermore, our sample preparation uses a simple isolation procedure. Numerous CYP450 phenotyping methods employed extensive extraction procedures for sample preparation such as dual liquid extraction or solid phase extraction which are costly and time consuming [10], [17], [18], [19], [20], [23],

• As shown in a previous report Donatti and Leite

  2020-08-06

  

  As shown in a previous report (Donatti and Leite-Panissi, 2011), microinjection of CRF into the BLA or CeA of the guinea pig increased the duration of TI episodes compared to control episodes (Fig. 2A–D). However, when the microinjection of CRF into the BLA or CeA was preceded by the injection of CP

• Several studies have shown that the

  2020-08-06

  

  Several studies have shown that the catalytic activity of Csk can be modulated to some extent [5], [6], [7]. The crystal structure of four active and two inactive full-length Csk molecules provides the molecular basis to study how control of Csk activity is achieved [8]. The crystal data show that i

• br TRIM E ubiquitin ligases The KEGG

  2020-08-05

  

  TRIM E3 ubiquitin ligases The KEGG database shows that TRIMs belong to Ubiquitin ligases (E3), under the Single Ring-Finger type E3 class in Homo sapiens. With the concept that similar structures perform similar functions at biochemical level, the width of TRIM family grew significantly, now cont

• br Restenosis after angioplasty remains a remarkable challen

  2020-08-05

  

  Restenosis after angioplasty remains a remarkable challenge, although drug-eluting stents have reduced the incidence of restenosis considerably . Vascular smooth muscle Omeprazole (VSMCs) play a pivotal role in the development of intimal thickening and restenosis. VSMCs proliferate and migrate fro

• It has been suggested that NHEJ is the initial default

  2020-08-05

  

  It has been suggested, that NHEJ is the initial default pathway for DSB repair and, when NHEJ fails, HR may take over [56], [57]. Thus, the affinity of DNA-PKcs for the crossover region of Holliday junctions could anticipate an unexpected backup mechanism for the down regulation of improper recombin

• Cell Culture and Transfection Cos cells American Type Cultur

  2020-08-05

  

  Cell Culture and Transfection: Cos7 cells (American Type Culture Collection) were cultured in Dulbecco\'s Modified Eagle Medium (DMEM; HyClone) supplemented with 10% Fetal Bovine Serum (FBS; HyClone) and Penicillin, Streptomycin, and Glutamine (Corning). Cells were maintained in a humidified Bleomyc

• Furthermore the Langerhans cell infiltrate in skin

  2020-08-05

  

  Furthermore, the Langerhans cell infiltrate in skin biopsies from RG7155-treated patients will be analyzed since keratinocyte derived IL-34 was identified as their survival factor (Greter et al., 2012). Microglia, the other macrophage population regulated by neural progenitor and glial cell-derived

• According to Graeff Graeff innate

  2020-08-05

  

  According to Graeff (Graeff, 1990), innate fear is mediated by neural circuitry that consists of at least the amygdala, medial hypothalamus and periaqueductal grey matter. In particular, the BLA has been considered to be a structure closely related to emotional responses to fear, stress and anxiety

• Forskolin is a labdane diterpene produced from the

  2020-08-05

  

  Forskolin is a labdane diterpene produced from the root of Coleus forskohlii (Bhat et al., 1977). Its extract has been recorded in Ayurveda medicine since ancient times and its medicinal value has been studied since early-1980s (Bristow et al., 1984; Kavitha et al., 2010). Early studies have suggest

• Concentration response profiles are presented in EC values a

  2020-08-05

  

  Concentration–response profiles are presented in . EC50 values and potencies relative to reference compounds are shown in . As expected, all synthetic progestogens tested were potent agonists of hPR (A). All 19-nortestosterone-derived progestins were more potent hPR agonists than the endogenous liga

14176 records 762/946 page Previous Next First page 上5页 761762763764765 下5页 Last page