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Many processes can lead to
2019-09-11
Many processes can lead to changes in soil P pools over time. Plant-available P (when measured as DGT P) decreased over time for the INORG-P treatment (Fig. 1a). Orthophosphate can be stabilised with cations such as calcium to produce insoluble phosphates, reducing plant-available P (Bünemann et al.
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br Results br Discussion MSCs derived from the bone marrow
2019-09-10
Results Discussion MSCs derived from the bone marrow and adipose tissue have been shown to promote the growth and metastatic ability of breast cancer and other human malignancies, but the mechanisms are incompletely understood (Barcellos-Hoff et al., 2013, Cuiffo et al., 2014, Del Pozo Martin
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N fowleri enters the host through the nasal cavity and
2019-09-10
N. fowleri enters the host through the nasal cavity and travels via the olfactory nerve into the Tetracaine HCl pathway where it causes PAM (Visvesvara and Stehr-Green, 1990). The ameba most commonly infects healthy young adults and children and is able to evade the immune system but also elicits e
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In conclusion by investigating the
2019-09-10
In conclusion, by investigating the cysteine protease transcriptome in soybean nodules, we found a number of cysteine proteases belonging to the C1 and C13 families strongly up-regulated following drought exposure such as C1 cysteine protease Glyma.14G085800 and C13 cysteine proteases Glyma.17G23070
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br Prostaglandin D PGD is derived from the metabolism
2019-09-10
Prostaglandin D (PGD) is derived from the metabolism of arachidonic ubiquitin by cyclooxygenases and downstream PGD synthases. In the immune system, PGD is mainly produced by mast cells but also although at lower levels, by macrophages and Th2 lymphocytes. PGD binds to three different receptors,
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Recent data obtained with etifoxine suggest that facilitatio
2019-09-10
Recent data obtained with etifoxine suggest that facilitation of GABAergic inhibition may be also associated with an indirect mechanism implying activation of the peripheral benzodiazepine receptor with a subsequent increase in neurosteroid production (Schlichter et al., 2000, Verleye et al., 2005).
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It has long been known that native BChE
2019-09-10
It has long been known that native BChE is a major factor in the inactivation of cocaine, an ester-type drug of abuse [190]. But recently some researchers conceived the idea that BChE mutations could improve that function to a point that would favorably impact cocaine overdose. Rapid progress was ma
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Hepatocyte proliferation is accompanied by changing
2019-09-10
Hepatocyte proliferation is accompanied by changing gene expression [1,2]. as two of the three estrogen receptors are transcription factors: Estrogen Receptor alpha (ERα) and ERβ [[3], [4], [5]]. The most potent ligand estradiol, binds to ERα/ERβ and exerts changing cognate gene transcription [5]. O
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The use of the periplasmic fraction as starting material and
2019-09-10
The use of the periplasmic fraction as starting material and the presence of a unique purification step concurred in improving the purification yield to 25.3%, which is significantly higher than what obtained with the previous purification protocol (6.7%). In addition, the analysis of the kinetic co
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Constitutive activity of Ras Raf MEK ERK pathway plays
2019-09-10
Constitutive activity of Ras/Raf/MEK/ERK pathway plays a critical role on melanoma growth, thus inhibition of activity of Ras, Raf and MEK can reduce ERK activity, leading to a decrease in melanoma cell proliferation, survival and invasion (Burotto et al., 2014; Paluncic et al., 2016). Our results a
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Multiple technologies exist for analyzing the contents
2019-09-10
Multiple technologies exist for analyzing the contents of single cells, including single-cell DNA sequencing, RNA expression analysis, and protein level and activity measurements (Hu et al., 2018; Narrandes & Xu, 2018; Ortega et al., 2017; Wang & Navin, 2015). Single-cell DNA sequencing is generally
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Although the reasons why viral RNA does
2019-09-10
Although the reasons why viral RNA does not bind to and activate PKR in WNV-infected cells are not known, some of the known characteristics of flavivirus infections provide possible clues. The viral BMS-303141 protein forms dimers that associate with ER membranes and viral RNA (Lindenbach et al., 2
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Lymphocyte mobility and homing is modulated by the chemoattr
2019-09-10
Lymphocyte mobility and homing is modulated by the chemoattractant receptor subfamily of G protein-coupled receptors (GPCRs) (Campbell et al., 2003, Rot and von Andrian, 2004). B cell migration and position are controlled to a large extent by the lymphoid chemokines CXCL13, CXCL12, CCL19, and CCL21
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The strand domain swap in the UbV XR
2019-09-10
The β strand domain swap in the UbV.XR dimer appears to be a unique arrangement for a Ub-based dimer. In solution, free Ub has a KD of ∼5 mM for the monomer-dimer equilibrium, and the two subunits in the dimer adopt a range of relative orientations involving residues from Ub’s β sheet (Liu et al., 2
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Currently two approaches can be used individually
2019-09-10
Currently, two approaches can be used individually or combinedly to overcome weak immunogenicity of subunit Cinchonidine clinical (Bookstaver et al., 2018; Moyle, 2017; Vartak and Sucheck, 2016). The first is to design particulate antigens. Virus-like particles (VLPs), for example—mainly derived fr
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