• BI-847325 br Conflicts of interest br Financial support

  2019-08-29

  

  Conflicts of interest Financial support NZ is an Established Investigator of the Dutch Heart Foundation (2013T111) and is supported by an ERC Consolidator grant (617376) from the European Research Council and by a Vici grant from the Netherlands Organization for Scientific Research (NWO; 91818

• The aim of this study

  2019-08-28

  

  The aim of this study was to use molecular methods to characterise C. difficile isolates circulating in the Czech Republic from 2013 to 2015. Material and methods Discussion During a three-year period (2013–2015) a total of 32 hospitals voluntarily participated in this project, but only 11 ho

• Enolase as a plasminogen receptor and activator localized on

  2019-08-28

  

  Enolase, as a plasminogen receptor and activator localized on the surface of several helminths, can interact with the host fibrinolytic system (Yang et al., 2010, Du et al., 2009, de la Torre-Escudero et al., 2010). The enzyme is also one of excretory/secretory (ES) products in some helminths, such

• br Acknowledgement We acknowledge for funding support from M

  2019-08-28

  

  Acknowledgement We acknowledge for funding support from Maryada Foundation, a DoD/Army Contract No. W911NF-06-1-0095, and National Institutes of Health through the New England Center of Excellence for Biodefense (Grant AI057159-01). Introduction The Gram-negative bacterium Lysobacter sp. XL1

• We propose that unlike other autophagy genes the

  2019-08-28

  

  We propose that, unlike other autophagy genes, the specific increase in the expression of IRGM by pEIF2A plays a major role as a checkpoint allowing host cell survival by autophagy or host cell elimination by necroptosis. The localization of IRGM to the mitochondrial inner membrane, its ability to i

• Upstream Stimulatory Factor USF binding to the

  2019-08-28

  

  Upstream Stimulatory Factor (USF) binding to the −65 E-box is required for the regulation of FAS promoter activity in fasting/feeding [97], [98]. DNA-PK are identified as a USF-interacting protein [99]. In response to feeding/insulin, the transient double-stranded DNA breaks occurred during the tran

• In Arabidopsis the quartet qrt mutant enables the same

  2019-08-28

  

  In Arabidopsis the quartet1 (qrt1) mutant enables the same type of analysis of gametophytes (pollen) in sets of four (tetrads) derived from individual meioses 61., 62.. Pollen tetrads from one accession (Columbia-0) are used to pollinate a second polymorphic accessions (Landsberg erecta) resulting i

• br Experimental br Results and discussion br Conclusions In

  2019-08-28

  

  Experimental Results and discussion Conclusions In this work we presented the direct electrochemical behaviour of the Mo containing formate dehydrogenase, purified from D. desulfuricans, where the Mo centre redox features were observed. The results allowed to calculate the reduction potenti

• We found that both DDR and DDR

  2019-08-28

  

  We found that both DDR1 and DDR2 ECD increased matrix mineralization as compared to native cells, with the effect of DDR2 ECD being more prominent. Both soluble (DDR2/ECD) and membrane-bound DDR2 ECD (DDR2/-KD), when compared to wild-type cells, induced larger mineral deposits. In this regard, a rec

• br Experimental procedures br Introduction Perfluorooctane

  2019-08-28

  

  Experimental procedures Introduction Perfluorooctane sulfonate (PFOS) is an anthropogenic compound with high thermal, chemical and biological stability, which makes it a perfect ingredient for many industrial applications (Kissa, 2001). Nevertheless, these characteristics also mean that PFOS i

• br DUBs in regulation of critical steps in

  2019-08-27

  

  DUBs in regulation of critical steps in tumor metastasis Tumor metastasis comprises a complicated series of biological processes in terms of the invasion-metastasis cascade that requires cancer NSC 87877 mass to (1) migrate and invade from the origin sites through the extracellular matrix (ECM) t

• br Results br Discussion The structures presented here were

  2019-08-27

  

  Results Discussion The structures presented here were solved at high melatonin receptor agonist and show in detail how DDR1 achieves high affinity for imatinib and ponatinib, respectively. Both type II inhibitors bind in their more potent extended conformations to the inactive DFG-out conform

• To be a qualified non specific CYP inhibitor

  2019-08-27

  

  To be a qualified non-specific CYP inhibitor used as an in vitro or in vivo screening tool to distinguish CYP involvement in the overall metabolism, a complete inhibition of the entire metabolism catalyzed by CYPs in a simple experiment is desired. Based on our results, 100 μM atipamezole can comple

• Agglutinin like sequence ALS gene is well

  2019-08-27

  

  Agglutinin-like sequence (ALS) gene is well-characterized gene family in candidiasis due to its importance in pathogenicity of C albicans. Previously, C. albicans ALS1 gene product was reported as cell surface protein that mediates adherence to endothelial and epithelial Fisetin kinase in vitro and

• From materials science it is known that

  2019-08-27

  

  From materials science, it is known that the differences in the annealing temperature is the main factor that mostly influences La (Takai et al., 2003, Cançado et al., 2006). In analogy, controlling the pyrolysis temperature and KU-0060648 during residues burning might be a key aspect to reproduce

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