• CB-5083: A Selective p97 Inhibitor for Disrupting Protein...

  2025-09-22

  Explore the scientific basis and research applications of CB-5083, a potent oral bioavailable p97 inhibitor, in disrupting protein homeostasis and inducing apoptosis in cancer cells. This article reviews mechanistic insights, experimental findings, and its role in tumor growth inhibition models.

• 3X (DYKDDDDK) Peptide: Enabling Advanced Protein Interact...

  2025-09-19

  Explore the versatile applications of the 3X (DYKDDDDK) Peptide in protein research, with a focus on its role in affinity purification, immunodetection, and membrane protein studies. This article highlights the peptide’s unique features and its impact on elucidating virus-host interactions.

• Advancing Post-Transcriptional RNA Processing with HyperS...

  2025-09-18

  Explore the scientific foundation and applications of the HyperScribe™ Poly (A) Tailing Kit for polyadenylation of RNA transcripts, with a focus on mRNA stability enhancement and translation efficiency improvement in advanced molecular biology research.

• A large number of aldose reductase inhibitors have been

  2025-03-03

  

  A large number of aldose reductase inhibitors have been prepared synthetically, and a limited number of them are therapeutically used. However, none of them is satisfactory. Here, Cannabis extracts with high content of non-psychotropic phytocannabinoids CBD/CBDA or CBG/CBGA showed statistically sign

• The role of circulating physiologic concentrations of FGF in

  2025-03-03

  

  The role of circulating physiologic concentrations of FGF21 in glucose metabolism, however, remains unclear. Circulating FGF21 levels in obese and diabetic rodents, and in patients with type 2 diabetes are significantly higher than those in controls without diabetes [4], [5], [6]. On the other hand,

• An alternative approach to the administration of ADO agonist

  2025-03-03

  

  An alternative approach to the administration of ADO agonists is to amplify the actions of endogenous ADO by inhibiting the ADO-metabolizing enzyme, ADO kinase (AK). Inhibition of AK has the net effect of potentiating the local concentration and the effects of ADO in the extracellular compartment. T

• Finasteride has been shown to be

  2025-03-03

  

  Finasteride has been shown to be a mechanism-based inhibitor of 5AR-2 [9]. Finasteride acts as an alternate substrate for 5AR-2 and is initially bound in an extremely stable enzyme-bound NADP-dihydrofinasteride adduct which is ultimately processed to dihydrofinasteride. The NADP-dihydrofinasteride a

• A unique finding in this study is

  2025-03-01

  

  A unique finding in this study is that 12/15-LO influences CREB phosphorylation in the murine brain. While previous reports have found that knockout of 5-lipoxygenase, a related enzyme that also uses arachidonic IU1 for substrate, can regulate CREB phosphoryation in the context of Alzheimer's diseas

• br Results br Discussion Context specific and dynamic

  2025-03-01

  

  Results Discussion Context-specific and dynamic post-translational protein modifications are well-established regulators of the signaling pathways that protect eukaryotic DNA integrity during the tremendous task of replication. Advancements in speed, resolution, and sensitivity of MS-based tec

• br Experimental section br Acknowledgments br Introduction A

  2025-03-01

  

  Experimental section Acknowledgments Introduction Adipose is a major endocrine organ which releases a range of bioactive agents [1]. Selected adipose depots have been established as sites of sex steroid metabolism [1]. Subcutaneous and visceral adipose express high levels of aromatase, cap

• Furthermore because most of foods and beverages have been co

  2025-03-01

  

  Furthermore, because most of foods and beverages have been consumed after processing, researchers have focused on the effects of processing (e.g. blanching, cooking, drying, cooling, freezing, high-pressure treatment, pulsed electric field) on total antioxidant capacity of foods. In general, there w

• Experimentally the ECD spectrum of showed three

  2025-03-01

  

  Experimentally, the ECD spectrum of 1 showed three ECD bands: positive ones at 260 and 200nm, and a negative one at 230nm (Fig. 4). Meanwhile, there is only one broad positive ECD band starting from 300nm in the ECD spectrum of 2. ECD spectra of 1 and its derivatives attracted great interest because

• br Material and methods br Results

  2025-03-01

  

  Material and methods Results Table 1 shows that in addition to Leu/CysAP and DPPIV, genes for AspAP, ArgAP, MetAP, APM and PSA are expressed in adipocytes. The kinetic parameters of these AP are also shown in Table 1, revealing that APM has the highest Vmax and catalytic efficiency (Kcat/Km),

• Pregnane X receptor PXR is

  2025-03-01

  

  Pregnane X receptor (PXR) is a nuclear receptor that plays an important role in regulation of metabolism and disposition of structurally diverse xenobiotics as well as endogenous steroids and bile acids (Bertilsson et al., 1998, Kliewer et al., 1998, Lehmann et al., 1998). PXR regulates the metaboli

• Among the enzymes involved in adenosine metabolism

  2025-03-01

  

  Among the enzymes involved in adenosine metabolism, adenosine kinase plays an important role in regulating formation and release of endogenous adenosine in cardiomyocytes as well as vascular endothelial cells Decking et al., 1997, Kowaluk et al., 1998, Smolenski et al., 1994. Inhibition of adenosine

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